As the Short family's lives unfold in four brief stories each week, they try to savor the moments that add up to what life's all about.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather (Short) Hughes
- Thomas Sadoski as Matthew "Matt" Short
- Zoe Lister-Jones as Jennifer "Jen" Collins-Short
- Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
- Angelique Cabral as Colleen Brandon Ortega
- Niall Cunningham as Tyler Hughes
- Holly Barrett as Samantha "Sam" Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Bertram Short
- Dianne Wiest as Dr. Joan (Pirkle) Short
- Jordan Peele as Chad
- Susan Park as Dr. Sally Hong
- Exie Andrade as Policeman (credited as Exie Booker)
- Stacie Greenwell as Delivery Nurse
- The airdate was announced to be on September 21, 2015.