John and Joan disagree with their neighbors, Jerry and Pam, about who gets to use the hot tub when new property lines are drawn. Also, Greg and Jen invite their exterminator and his wife over for dinner, Matt and Colleen make an effort to be friends, and Tim is terrified to perform minor surgery on John.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather (Short) Hughes
- Thomas Sadoski as Matthew "Matt" Short
- Zoe Lister-Jones as Jennifer "Jen" Collins-Short
- Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
- Angelique Cabral as Colleen Brandon Ortega
- Niall Cunningham as Tyler Hughes
- Holly Barrett as Samantha "Sam" Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Bertram Short
- Dianne Wiest as Dr. Joan (Pirkle) Short
- Martin Starr as Oscar
- J.B. Smoove as Darryl
- Ayden Mayeri as Tulip
- Pam Trotter as Pam
- Colin Hanks mentions sleeping with a Playboy Bunny. He played Oliver in the movie The House Bunny and is Playboy Mate Anna Farris' love interest.