Firstborn Tyler having moved to college, Tim and Heather want a fourth baby 'to do it all right at last', but his rare shot at sex is ruined as she takes offense at anything he phrases too honestly. Penniless Matt has moved back home with dad John, whose tequila-in-tank trick only gets his derelict car running long enough to reach his unaffordable restaurant date Colleen, which still works out great as she was stood up as bride and he offers to come along trying to cancel her reservation. Cool uncle Matt helps Tyler cover up his 'drug stash' for the ex-cons charity moving company staff at Greg's new home. As Heather's weird gynecologist predicted, she's off sex after peeking at her postnatal vagina, but 'the glove' gives Greg a last shot at resuming intercourse.
- Colin Hanks as Greg Short
- Betsy Brandt as Heather (Short) Hughes
- Thomas Sadoski as Matthew "Matt" Short
- Zoe Lister-Jones as Jennifer "Jen" Collins-Short
- Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
- Angelique Cabral as Colleen Brandon Ortega
- Niall Cunningham as Tyler Hughes
- Holly Barrett as Samantha "Sam" Hughes
- Giselle Eisenberg as Sophia Hughes
- James Brolin as John Bertram Short
- Dianne Wiest as Dr. Joan (Pirkle) Short
- Stephnie Weir as Bernadette
- Rhys Darby as Teddy
- Jordan Black as Hotel Manager
- Billy Malone as Aaron