Season 1

The first season of the family sitcom as Life in Pieces which was premiered on September 21, 2015 and concluded on March 31, 2016 with the consists of 22 episodes.

Main

 * Colin Hanks as Greg Short
 * Betsy Brandt as Heather (Short) Hughes
 * Thomas Sadoski as Matthew "Matt" Short
 * Zoe Lister-Jones as Jennifer "Jen" Collins-Short
 * Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
 * Angelique Cabral as Colleen Brandon Ortega
 * Niall Cunningham as Tyler Hughes
 * Holly Barrett as Samantha "Sam" Hughes
 * Giselle Eisenberg as Sophia Hughes
 * James Brolin as John Bertram Short
 * Dianne Wiest as Dr. Joan (Pirkle) Short
 * Hunter King as Clementine Hughes

Recurring

 * Ann Guilbert as Shirley "GiGi" Pirkle
 * Jordan Peele as Chad
 * Fortune Feimster as Dougie

Trivia

 * The series consists of 22 episodes on October 27, 2015.