Season 4

The fourth and final season of the family sitcom as Life in Pieces which was premiered on April 18 and concluded on June 27, 2019, with the consists of 13 episodes.

Main

 * Colin Hanks as Greg Short
 * Betsy Brandt as Heather (Short) Hughes
 * Thomas Sadoski as Matthew "Matt" Short
 * Zoe Lister-Jones as Jennifer "Jen" Collins-Short
 * Dan Bakkeddahl as Dr. Timothy "Tim" Hughes, M.D.
 * Angelique Cabral as Colleen Brandon Ortega
 * Niall Cunningham as Tyler Hughes
 * Holly Barrett as Samantha "Sam" Hughes
 * Giselle Eisenberg as Sophia Hughes
 * James Brolin as John Bertram Short
 * Dianne Wiest as Dr. Joan (Pirkle) Short
 * Hunter King as Clementine Hughes
 * Ana Sophia Heger as Lark Short

Guest

 * Nat Faxon as Hayes
 * Vivaan Bisoi as Lucas

Trivia

 * On May 12, 2018, the series was renewed for a fourth season along with Criminal Minds and Man with a Plan.
 * On February 25, 2019, the series was scheduled on Thursday, April 18 at 9:30 pm, right after Mom.
 * On May 10, 2019, it was cancelled after four seasons and it was clear space in getting four new sitcoms in the fall 2019 and mid-season schedule, led to the show's demise.